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Observe Closely (1)pentobarbital will reduce the level or influence of osilodrostat by impacting hepatic/intestinal enzyme CYP3A4 metabolism.pentobarbital decreases amounts of panobinostat by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Powerful CYP3A4 inducers can reduce panobinostat levels by ~70% and produce treatment